Faculty

Libin Ye

Associate Professor

CONTACT

Office: BSF 216
Phone: (813) 974-6007
Lab: BSF 258-264
Email

Lab website

• Ye Lab

EDUCATION

• Ph.D., Nanjing Agricultural University, Nanjing, China (2008)
• Postdoctoral Fellow, University of Illinois at Urbana-Champaign, Urbana, USA, 2011-2012
• Postdoctoral Fellow, University of Pittsburgh Medical Center, Pittsburgh, USA, 2012-2013
• Postdoctoral Fellow, University of Toronto, Toronto, Canada, 2013-2018

RESEARCH

GPCRs constitute the largest transmembrane protein family with more than 800 members. They serve as gatekeepers, controlling transduction for a variety of physiological and pathogenic signals, and are involved in almost every aspect of physiological activities in our human body. It is therefore easy to imagine that any GPCR signaling dysfunction probably leads to a disease such as cancer, cardiac failure, neurological diseases, obesity, and infectious diseases, etc. Although only 10% of GPCRs have been subjected to drug discovery, they are already targeted by nearly 35% of FDA-approved medications, indicating a continued tremendous potential in drug discovery. In brief, my lab’s research focuses on

• Developing novel tools in understanding molecular mechanism of GPCR activation,
• Innovating drug discovery platforms, and
• Exploring new medications for GPCR causative diseases.

In addition, we also study a set of dinoflagellate GPCRs related to the red tide blooms, with an aim to improve coastal ecosystem, understand unicellular GPCR in the evolution, and mitigate dino-associated public health issues.

GRADUATE STUDENTS

• Aidan McFarland
• Xudong Wang
• Wenkai Sun
• Nathaniel Hays