Faculty & Staff
Loree Heller
Education
PhD, University of South Florida College of Medicine, Tampa, FL, Biochemistry and
Molecular Biology
MS, Long Island University, Greenvale, NY, Medical Microbiology and Immunology
BS, Oregon State University, Corvallis, OR, Microbiology
Research
Nucleic acid electrotransfer, Non-viral gene therapies, Pattern recognition receptors
Memberships
American Society for Clinical Pathology
American Society of Gene and Cell Therapy
American Association of Immunologists
American Association for Cancer Research
National Academy of Inventors
International Society for Electroporation
Research Grants
NIH NCI R01 “DNA-specific pattern recognition receptor activation following DNA electroporation”
Recent Publications
Conniff, Amanda & Cason, Aneeshea & Alvarado, Juliana & Bhandary, Manya & Patel, Shreena & Singh, Julie & Heller, Richard & Heller, Loree. (2024). Direct Plasmid DNA Transfection into Differentiated Mouse C2C12 Myotubes. Re:GEN Open. 4. 1-8. 10.1089/regen.2023.0026.
Conniff, Amanda & Tur, Jared & Kohena, Kristopher & Zhang, Min & Gibbons, Justin & Heller, Loree. (2023). DNA Electrotransfer Regulates Molecular Functions in Skeletal Muscle. Bioelectricity. 10.1089/bioe.2022.0041.
Sales, Amanda & Tur, Jared & Kohena, Kristopher & Zhang, Min & Gibbons, Justin & Heller, Loree. (2022). Transcriptomic Analysis of the Acute Skeletal Muscle Effects after Intramuscular DNA Electroporation Reveals Inflammatory Signaling. Vaccines. 10. 2037. 10.3390/vaccines10122037.
Bhandary, Manya & Sales, Amanda & Miranda, Kaitlyn & Heller, Loree. (2022). Acute Effects of Intratumor DNA Electrotransfer. Pharmaceutics. 14. 2097. 10.3390/pharmaceutics14102097.
Sales, Amanda & Encalada, G & Patel, S & Bhandary, M & Al-Takrouri, F & Heller, Loree. (2022). Poly(I:C) transfection induces a pro-inflammatory cascade in murine mammary carcinoma and fibrosarcoma cells. RNA Biology. 19. 841-851. 10.1080/15476286.2022.2084861.
Heller, Loree & Shi, Guilan & Synowiec, Jody & Heller, Richard. (2022). Abstract 3289: PD-1 peptide/IL-12 combination gene therapy for the treatment of melanoma. Cancer Research. 82. 3289-3289. 10.1158/1538-7445.AM2022-3289.
Bošnjak, Maša & Znidar, K. & Sales, Amanda & Jesenko, Tanja & Markelc, B. & Semenova, Nina & Tur, J. & Kohena, K. & Kranjc, Simona & Heller, Loree & Cemazar, Maja. (2022). In vitro and in vivo correlation of skin and cellular responses to nucleic acid delivery. Biomedicine & Pharmacotherapy. 150. 113088. 10.1016/j.biopha.2022.113088.
Heller, Loree & Znida, Katarina & Bošnjak, Maša & Sales, Amanda & Jesenko, Tanja & Markelc, Bostjan & Tur, Jared & Semenova, Nina & Cemazar, Maja. (2022). Comparison of DNA sensing by non-immune cells and tissues. The Journal of Immunology. 208. 164.06-164.06. 10.4049/jimmunol.208.Supp.164.06.
Heller, Loree & Bulysheva, Anna & Arpag, S. & Sales, Amanda & Kohena, K. & Shi, G. & Semenova, Nina & Heller, Richard & Cemazar, Maja. (2021). Growth environment influences B16.F10 mouse melanoma cell response to gene electrotransfer. Bioelectrochemistry. 140. 107827. 10.1016/j.bioelechem.2021.107827.
Dolezalova, Eva & Malik, Muhammad & Heller, Loree & Heller, Richard. (2021). Delivery and expression of plasmid DNA into cells by a novel non-thermal plasma source. Bioelectrochemistry. 140. 107816. 10.1016/j.bioelechem.2021.107816.
Bulysheva, Anna & Heller, Loree & Francis, Michael & Varghese, Frency & Boye, Carly & Heller, Richard. (2021). Monopolar Gene Electrotransfer Enhances Plasmid DNA Delivery to Skin. Bioelectrochemistry. 140. 107814. 10.1016/j.bioelechem.2021.107814.
Jesenko, Tanja & Bošnjak, Maša & Markelc, Bostjan & Sersa, Gregor & Znidar, Katarina & Heller, Loree & Cemazar, Maja. (2020). Radiation Induced Upregulation of DNA Sensing Pathways is Cell-Type Dependent and Can Mediate the Off-Target Effects. Cancers. 12. 10.3390/cancers12113365.
Heller, Loree & Thinard, Reynald & Chevalier, Melanie & Arpag, Sezgi & Jing, Yu & Greferath, Ruth & Heller, Richard & Nicolau, Claude. (2020). Secretion of proteins and antibody fragments from transiently transfected endothelial progenitor cells. Journal of Cellular and Molecular Medicine. 24. 10.1111/jcmm.15511.
PATENTS
US 6,714,816 B1 (Issued March 30, 2004): Electroporation and electrophoresis system and method for achieving molecular penetration into cells in vivo. Inventors: Heller R, Gilbert R, Jaroszeski MJ, Heller LC, Lucas ML. Assignee: University of South Florida. https://www.google.com.ar/patents/US9610364
US 7,668,592 B2 (Issued February 23, 2010): Electroporation and electrophoresis system and method for achieving molecular penetration into cells in vivo. Inventors: Heller R, Gilbert R, Jaroszeski MJ, Heller LC, Lucas ML. Assignee: University of South Florida. https://www.google.com.ar/patents/US7668592
US 8,802,643 (Issued August 12, 2014) Method for the treatment of malignancies, Inventors: Heller, R., Heller, L.C. Assignee: University of South Florida. https://www.google.com.ar/patents/US8802643
US 8,895,248 (Issued November 25, 2014) Method for Detecting Salmonella Species By Assaying Outer Membrane Porin F (ompF). Inventors: Tatavarthy, A., Cannons, A.C., and Heller, L.C. Assignee: University of South Florida. https://www.google.com.ar/patents/US8895248
US 9,410,212 (Issued August 9, 2016) Kit for Detecting Salmonella Species By Assaying Outer Membrane Porin F (ompF). Inventors: Tatavarthy, A., Cannons, A.C., and Heller, L.C. Assignee: University of South Florida. https://www.google.com.ar/patents/US9410212
US 9,610,364 (Issued April 4, 2017) Method for the treatment of malignancies, Inventors: Heller, R., Lucas, M.L., Heller, L.C. Assignee: University of South Florida. https://www.google.com.ar/patents/US9610364