Development of Bio-therapeutic Systems, Devices and Compounds for Treating Sensory Deficits; Emphasis on Bench-to-Bedside Investigations of the Auditory System, and Translational Research on Deafness and Other Neuroengineering Applications.

Vision Systems, Neural Signal Processing, Computational Modeling, Retinal Physiology and Disease

EGN 3000L, BME 3312, BME 4056C, BME 4057C

Nano-biomechanics of human aortic disease; Collagen mineralization in human tissue; Toughening mechanisms in mineralized tissues.

Gene Delivery, Tissue Engineering, Regenerative Medicine

Investigate the molecular mechanism of age-related hearing loss and especially characterize the role of autophagy, a highly conserved cellular process, in the auditory system with aging.

The major focus is to develop effective drug and gene delivery. The emphasis is on translational studies that include the development and testing of new protocols or devices that can be utilized for potential therapies for cancer, wound healing, metabolic disorders and vascular diseases (peripheral and coronary ischemia) as well as vaccine and immunotherapy protocols.

Drug and Gene Delivery, Electrofusion, Biomedical Instrumentation, Electrophoresis

Diffuse optical tomography (DOT), photoacoustic tomography (PAT), fluorescence molecular tomography (FMT), and bioluminescence tomography (BLT).

Acousto-Bioelectronics, Sensor & Actuator, Implantable Microdevices, BioMEMS

Tissue engineering; Tissue-mimetic biomaterials; Preclinical translation of engineered tissues; Cell-biomaterial interactions;Tissue culture bioreactors; Cardiovascular engineering; Collagen; Elastin

Soft Tissue Biomechanics; Glaucoma; Ocular Biomechanics; Tissue Damage; Tendon Biomechanics

EGN 3365, BME 4931/6931 Statistics for BME

Research in the Spirou laboratory is focused on formation of neural circuits in early development and on construction of connectomes, or neural wiring diagrams, at nanoscale resolution. The generation of large image volumes for this work necessitated development of tools to understand these complex data sets. Leveraging long-standing interest in 3D reconstruction of brain structure, he and collaborators joined the revolution in immersive virtual reality to develop software for viewing, annotating and analyzing images. Their software, called syGlass, is marketed by their company, IstoVisio, Inc., which began operation in summer, 2017.

Optical-based imaging technologies for in vivo visualization of tissue at both the macroscopic and microscopic scales.

BME 3053, BME 3082, BME 4882, BME 4883